Expression of CD97 in human skeletal muscle fibers
CD97 is a member of the EGF-TM7 subfamily of adhesion G-protein coupled receptors (GPCR) which are characterized by an unusual large extracellular region, possessing tandemly arranged epidermal growth factor (EGF)-like domains and a seven-span transmembrane region (TM7). The aim of the study was to investigate expression of CD97 in human skeletal muscle fibers by immunohistological analysis and immunofluorescence confocal microscopy. It was shown that CD97 is expressed in both slow and fast fibers. The quantitive analysis revealed that the percentage of CD97 strongly positive slow fibers is significantly higher than percentage of CD97 strongly positive fast fibers. Thus our date supposes the yet unknown role of CD97 in slow human skeletal muscle fibers.
fast and slow skeletal muscle fibers, GPCR adhesion class, CD97, MHC fast, MHC slow
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