The study of tight junction proteins in human pleura

  • Georgy Volgin General Hospital 3, 5, Kosaya Liniya, Saint Petersburg, 199026, Russian Federation
  • Elena Polyakova Saint Petersburg State University, 7–9, Universitetskaya nab., Saint Petersburg, 199034, Russian Federation
  • Alexander Markov Saint Petersburg State University, 7–9, Universitetskaya nab., Saint Petersburg, 199034, Russian Federation

Abstract

The present study shows for the first time an expression of tight junction proteins in human pleura. Some of them form paracellular channels, which specifically mediate the permeability of pleural mesothelium. Other proteins decrease permeability of the tight junctions to ions, molecules and cells. We report that tight junctions provide barrier function of pleural mesothelium, which helps to control the volume and composition of liquid lubricating pleural surfaces.

Keywords:

human pleura, mesothelium, claudins, occludin, transmesothelial resistance

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Published
2012-09-03
How to Cite
Volgin, G., Polyakova, E., & Markov, A. (2012). The study of tight junction proteins in human pleura. Biological Communications, (3), 68–78. Retrieved from https://biocomm.spbu.ru/article/view/3357
Section
Full communications