The study of tight junction proteins in human pleura
The present study shows for the first time an expression of tight junction proteins in human pleura. Some of them form paracellular channels, which specifically mediate the permeability of pleural mesothelium. Other proteins decrease permeability of the tight junctions to ions, molecules and cells. We report that tight junctions provide barrier function of pleural mesothelium, which helps to control the volume and composition of liquid lubricating pleural surfaces.
human pleura, mesothelium, claudins, occludin, transmesothelial resistance
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