Biochemical mechanisms of Mycobacterium tuberculosis drug resistance
Many countries of the world have seen the spread of tuberculosis (TB) as a result of not only such factors as social and economic recession and spread of HIV infection but biological changes of the pathogen — generation of Mycobacterium tuberculosis strains resistant to many drugs. Drug resistance significantly reduces efficiency of TB therapy. Mutations associated with drug resistance were described for many anti-tuberculosis drugs. However the frequency of these drug-resistance mutations in Mycobacterium tuberculosis strains may vary in different geographical regions. Here we describe the mechanisms of action and resistance to major anti-tuberculosis drugs.
tuberculosis, ani-tuberculosis drugs, drug resistance
Articles of Biological Communications are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.