Biochemical mechanisms of Mycobacterium tuberculosis drug resistance

  • Ekaterina Chernyaeva Saint Petersburg State University, 7–9, Universitetskaya nab., Saint Petersburg, 199034, Russian Federation


Many countries of the world have seen the spread of tuberculosis (TB) as a result of not only such factors as social and economic recession and spread of HIV infection but biological changes of the pathogen — generation of Mycobacterium tuberculosis strains resistant to many drugs. Drug resistance significantly reduces efficiency of TB therapy. Mutations associated with drug resistance were described for many anti-tuberculosis drugs. However the frequency of these drug-resistance mutations in Mycobacterium tuberculosis strains may vary in different geographical regions. Here we describe the mechanisms of action and resistance to major anti-tuberculosis drugs.


tuberculosis, ani-tuberculosis drugs, drug resistance


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How to Cite
Chernyaeva, E. (2012). Biochemical mechanisms of <em>Mycobacterium tuberculosis</em&gt; drug resistance. Biological Communications, (2), 77–91. Retrieved from
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