The effect of alpha- and beta- adrenoblockers on the ability of adrenaline to change the osmotic resistance of erythrocytes of nonpregnant women
The effect of adrenaline and three adrenoblockers on the osmotic resistance of erythrocytes (ORE) has been studied on the example of 116 nonpregnant women. The ORE was estimated by the number of nonhemolyzed erythrocytes subjected to the exposure in distilled water (DW). It is established that an ability of adrenaline to raise or reduce the ORE depends on its concentration, erythrocyte fraction and level of reproductive hormones. Obzidan increased an ability of adrenaline to raise the ORE, while atenolol, nicergoline or their mixture decreased this ability. This fact means that an increase of the ORE under the influence of adrenaline is caused by activation of alpha-adrenoreceprors (AR) and, to a lesser degree, of beta1-AR, and a decrease of the ORE is caused by activation of beta2-AR.
erythrocytes, osmotic resistance, adrenoreactivity, adrenoreceptors, adrenaline, adrenoblockers
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