The effects of disturbance in neurumediator systems on lipid peroxidation and superoxide dismutase activity in rat brain cortex, hippocampus and striatum

  • Leonid Libin Saint Petersburg State University, 7–9, Universitetskaya nab., Saint Petersburg, 199034, Russian Federation
  • Sergei Dagaev Institute of Toxicology, 1, Bekhtereva Str., Saint Petersburg, 192019, Russian Federation
  • Larissa Kubarskaja Institute of Toxicology, 1, Bekhtereva Str., Saint Petersburg, 192019, Russian Federation
  • Natalia Eschenko Saint Petersburg State University, 7–9, Universitetskaya nab., Saint Petersburg, 199034, Russian Federation

Abstract

The article reveals the activation of lipid peroxidation in rat brain structures (especially in striatum) after injection of selective D2 antogonist haloperidol (0,32 mg/kg, i/p), as well as after injection of haloperidol and ketamine (0,13 mg/kg, i/p) — the antagonist of NMDA-glutamic receptors. The experiments with haloperidol show that the superoxide dismutase activity was higher in brain structures of the rats with motor disturbances (katalepsy) in comparison with the rats without katalepsy.

Keywords:

haloperidol, ketamine, motor disturbances, katalepsy, lipid peroxidation, superoxide dismutase, rat brain cortex, hippocampus, striatum

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Published
2012-09-03
How to Cite
Libin, L., Dagaev, S., Kubarskaja, L., & Eschenko, N. (2012). The effects of disturbance in neurumediator systems on lipid peroxidation and superoxide dismutase activity in rat brain cortex, hippocampus and striatum. Biological Communications, (3), 98–105. Retrieved from https://biocomm.spbu.ru/article/view/3360
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