The prolonged effects of tetrapeptide-amide on dopamine and serotonin metabolism in brain structures

  • Elizaveta Dovedova Scientific Centre of Neurology, RAMS, Russian Federation
  • Natalia Eschenko Saint Petersburg State University, 7–9, Universitetskaya nab., Saint Petersburg, 199034, Russian Federation

Abstract

A single injection of tetrapeptide-amide d-Tyr-Ala-Gly-Phe-NH2 (500 mkg/kg, i/p) to rats or rabbits caused an increase of MAO A activity, but a decrease of MAO B activity, especially in nucleus caudatum in comparison with brain cortex. The changes of MAO A and B activities, of tryptophan- and tyrosine hydroxylases activities, and the changes of serotonin concentration were found within 30 min as well as 3 days after a single injection of tetrapeptide-amide.

Keywords:

tetrapeptide-amide, DSIP, dopamine, serotonin, monoaminoxidase A and B, tryptophan hydroxylase, tyrosine hydroxylase, brain cortex, nucleus caudatum

Downloads

Download data is not yet available.
Published
2012-09-03
How to Cite
Dovedova, E., & Eschenko, N. (2012). The prolonged effects of tetrapeptide-amide on dopamine and serotonin metabolism in brain structures. Biological Communications, (3), 90–97. Retrieved from https://biocomm.spbu.ru/article/view/3359
Section
Full communications