Platelet functional activity in rats under a prolonged regeme of regular exercise

Abstract

Purpose — to find out the possibility of long-term regular exercise restrain the increase in age-platelet activity in rats. The study included 26 healthy male rats 6 months age, experience during the 1.5 years of daily exercise. Control presented 124 healthy males dye-contained in the standard terms. In the control rats with increasing age there is a gradual increase in functional activity of platelets. Regular daily exercise in rats between 6 and 24 months life were able to stabilize the functional activity of platelets, inhibiting its gain with age. Physical activity in rats provided throughout the observation time preserving low number of places on the surface of the platelet thrombin inductor strong fixation. This was accompanied by a small stable activity of phospholipase C, containment diacylglycerol synthesis and protein kinase C with an inactive fosfolirirovaniem contractile proteins platelet system. A small amount of inositol triphosphate provided with slowing revenue Ca2+ from the depot of blood platelets, helping to reduce the severity of the preservation of actomyosin in close to its original level. Thus physical exercise provide inhibition of platelet aggregation with adenosine diphosphate indicating the fibrinogen receptor on platelets fiziologizatsiyu expression and activity of phospholipase A2 in them, allowing segregation of optimal amounts of arachidonic acid from membrane phospholipids. Refs 14. Table 1.

Keywords

platelet aggregation, ontogenesis, rats, physical activity

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References

Nozdrachev A. D. Ot genomiki k integrativnoi fiziologii [From genomics to integrative physiology]. Vestnik Rossiiskoi akademii nauk [Bulletin of the Russian Academy of Sciences]. 2005, vol. 75, no. 4, pp. 364–366. (In Russian)

Doncov V. I., Krut’ko V. N., Truhanov A. I. Medicina antistareniia: fundamental’nye osnovy [Anti-aging Medicine: Fundamentals]. Moskow, KRASAND Publ., 2010. 680 p. (In Russian)

Kishkun A. A. Biologicheskii vozrast i starenie: vozmozhnosti opredeleniia i puti korrekcii: rukovodstvo dlia vrachei [Biological age and aging: to be identified and ways of correction: a guide for physicians]. Moskow, GEOTAR-Media Publ., 2008. 976 p. (In Russian)

Matjushichev V. B., Shamratova V. G. Vozrastnye i polovye osobennosti vzaimosviazei parametrov ob’ema eritrotsitov i trombotsitov krovi cheloveka [Age and sex characteristics between the parameters of the volume of red blood cells and human blood platelets]. Vestnik of Saint Petersburg University. Series 3. Biology, 2010, issue 3, pp. 78–83. (In Russian)

Ivkin D. Ju., Grishina T. V., Burjakina A. V., Krjachko O. V., Kuz’menko N. V., Vasil’eva O. V., Stefanov V. E., Surma S. V., Shhegolev B. F. Izmenenie kolichestvennykh i kachestvennykh kharakteristik krovi svidetel’stvuiut o realizatsii kompensatornykh mekhanizmov krys k izmeneniiam magnitnogo polia Zemli (model’nye eksperimenty) [Change of quantitative and qualitative characteristics of blood evidence on the implementation of the compensatory mechanisms of rats to changes in the magnetic field of the Earth (model experiments)]. Vestnik of Saint-Petersburg University. Series 3. Biology, 2014, issue 1, pp. 87–97. (In Russian)

Kutafina N. V., Medvedev I. N. Trombotsitarnaia agregatsiia u klinicheski zdorovykh lits vtorogo zrelogo vozrasta, prozhivaiushchikh v Kurskom regione [Platelet aggregation clinically healthy persons of the second coming of age living in the Kursk region]. Uspehi gerontologii [Advances in gerontology], 2015, vol. 28, no. 2, pp. 321–325. (In Russian)

Wang J. S., Lin C.-C., Chen J.-K., Wong M.-K. Role of chronic exercise in decreasing oxidized LDLpotentiated platelet activation by enhancing platelet-derived no release and bioactivity in rats. Life Sci., 2000, vol. 66 (20), рр. 1937–1948.

Degtjareva O. N. Vliianie trenirovannosti k fizicheskoi nagruzke na pokazateli krovi i krovenapolnenie organov u krys [Effect of physical fitness to the load on the blood and blood supply of organs from rats]. Problemy biologii produktivnyh zhivotnyh [Problems of Biology productive animals], 2012, no. 3, pp. 30–35. (In Russian)

Medvedev I. N., Gromnackij N. I. Korrekciia trombocitarnogo gemostaza i snizhenie biologicheskogo vozrasta pri metabolicheskom sindrome [Correction of thrombocyte hemostasis and biological age reduction in metabolic syndrome]. Klinicheskaia medicina [Klinicheskaia meditsina], 2005, vol. 83, no. 8, pp. 54–57. (In Russian)

Rjabysheva S. S. Hronotropnaia funkciia serdca krys, podverzhennyh raznym dvigatel’nym rezhimam [Chronotropic heart function of rats exposed to various motor regimes]. Molodoi uchenyi [Young scientist], 2012, vol. 1, no. 1, pp. 69–72. (In Russian)

Volchegorskij I. A., Dolgushin I. I., Kolesnikov O. L., Cejlikman V. Je. Eksperimental’noe modelirovanie i laboratornaia otsenka adaptivnykh reaktsii organizma [Experimental modeling and laboratory evaluation of adaptive reactions of the organism]. Cheljabinsk, 2000, 167 p. (In Russian)

Medvedev I. N., Savchenko A. P., Zavalishina S. Yu., Krasnova E. G. Metodicheskie podkhody k issledovaniiu reologicheskikh svoistv krovi pri razlichnykh sostoianiiakh [Methodological approaches to the study of rheological properties of blood at various conditions]. Rossijskii kardiologicheskii zhurnal [Russian Journal of Cardiology], 2009, no. 5, pp. 42–45. (In Russian)

Kutafina N. V., Zavalishina S. Yu. Mehanizmy funkcionirovaniia sosudisto-trombocitarnogo gemostaza [The mechanisms of functioning of the vascular-platelet hemostasis]. Vestnik RUDN. Ser. «Ekologiia i bezopasnost’ zhiznedeiatel’nosti» [Bulletin of Russian Peoples’ Friendship University. Ser. “Ecology and life safety”], 2012, no. 1, pp. 30–37. (In Russian)

Medvedev I. N., Lapshina E. V., Zavalishina S. Yu. Aktivnost’ trombocitarnogo gemostaza u detei s iskrivleniiami pozvonochnika [Experimental methods for clinical practice: Activity of platelet hemostasis in children with spinal deformities]. Biulleten’ eksperimental’noi biologii i meditsiny [Bulletin of Experimental Biology and Medicine], 2010, vol. 149, no. 5, pp. 579–580. (In Russian)
Published
2016-12-26
How to Cite
MEDVEDEV, Ilya. Platelet functional activity in rats under a prolonged regeme of regular exercise. Biological Communications, [S.l.], n. 4, p. 99–107, dec. 2016. ISSN 2587-5779. Available at: <https://biocomm.spbu.ru/article/view/21>. Date accessed: 12 dec. 2017. doi: https://doi.org/10.21638/11701/spbu03.2016.407.
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