Distinct molecular mechanisms for development of brain asymmetries?
Brain and behavioral asymmetries are often associated with neurodevelopmental disorders, but have yet uncovered genetic and developmental mechanisms. A recent study (Vingerhoets et al., 2018), published in Brain Structure and Function, examined neural structural and functional asymmetries in a cohort of patients with situs inversus totalis, with and without primary ciliarly dyskinesia as a second diagnosis. The authors showed a potential for independent randomization of handedness, language dominance, and visceral laterality; this provides the first experimental hint that different mechanisms for symmetry breaking and molecular cascades may be involved in producing asymmetry of body and brain.
brain left-right structural asymmetry, situs viscerum inversus totalis, primary ciliarly dyskinesia, handedness, language dominance, developmental mechanisms, neurodevelopmental diseases
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