Distinct molecular mechanisms for development of brain asymmetries?

Yegor Malashichev

doi:10.21638/spbu03.2018.201

Authors

Yegor Malashichev Department of Vertebrate Zoology, Faculty of Biology, Saint Petersburg State University, Universitetskaya nab., 7–9, Saint Petersburg, 199034, Russian Federation; Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, ul. Acad. Pavlova, 12, Saint Petersburg, 197376, Russian Federation https://orcid.org/0000-0003-3813-5712

DOI:

https://doi.org/10.21638/spbu03.2018.201

Abstract

Brain and behavioral asymmetries are often associated with neurodevelopmental disorders, but have yet uncovered genetic and developmental mechanisms. A recent study (Vingerhoets et al., 2018), published in Brain Structure and Function, examined neural structural and functional asymmetries in a cohort of patients with situs inversus totalis, with and without primary ciliarly dyskinesia as a second diagnosis. The authors showed a potential for independent randomization of handedness, language dominance, and visceral laterality; this provides the first experimental hint that different mechanisms for symmetry breaking and molecular cascades may be involved in producing asymmetry of body and brain.

Keywords:

brain left-right structural asymmetry, situs viscerum inversus totalis, primary ciliarly dyskinesia, handedness, language dominance, developmental mechanisms, neurodevelopmental diseases

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References

Barth, K. A., Miklosi, A., Watkins, J., Bianco, I. H., Wilson, S. W. and Andrew, R. J. 2005. Fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses. Current Biology 15(9):844–850. https://doi.org/10.1016/j.cub.2005.03.047

Crow, T. J., Done, D. J. and Sacker, A. 1996. Cerebral lateralization is delayed in children who later develop schizophrenia. Schizophrenia Research 22(3):181–185. https://doi.org/10.1016/S0920-9964(96)00068-0

Davis, E. E. and Katsanis, N. 2012. The ciliopathies: a transitional model into systems biology of human genetic disease. Current Opinion in Genetics and Development 22(3):290–303. https://doi.org/10.1016/j.gde.2012.04.006

Herbert, M. R., Ziegler, D. A., Deutsch, C. K., O’Brien, L. M., Kennedy, D. N., Filipek, P. A., Bakardjiev, A. I., Hodgson, J., Takeoka, M., Makris, N. and Caviness, V. S. 2005. Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis. Brain 128(1):213–226. https://doi.org/10.1093/brain/awh330

Husken, U. and Carl, M. 2013. The Wnt/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. Mechanisms of Development 130:330–335. https://doi.org/10.1016/j.mod.2012.09.002

Lemay, M. and Kido, M. 1978. Asymmetries of cerebral hemispheres on computed tomograms. Journal of Computer Assisted Tomography 2(4):471–476.

Levchenko, A., Davtian, S., Petrova, N. and Malashichev, Y. 2014. Sequencing of five left-right cerebral asymmetry genes in a cohort of schizophrenia and schizotypal disorder patients from Russia. Psychiatric Genetics 24:75–80. https://doi.org/10.1097/YPG.0000000000000021

Levchenko, A., Davtian, S., Freylichman, O., Zagrivnaya, M., Kostareva, A. and Malashichev, Y. 2015. Beta-catenin in schizophrenia: Possibly deleterious novel mutation. Psychiatry Research 228(3):843–848. https://doi.org/10.1016/j.psychres.2015.05.014

Malashichev, Y. 2006. Is there a link between visceral and neurobehavioral asymmetries in development and evolution?; 33–44 in: Behavioral and Morphological Asymmetries in Veretbrates, edited by Malashichev, Y. B. and Deckel, W. Georgetown, TX: Landes Bioscience.

Malashichev, Y. B. and Wassersug, R. J. 2004. Left and right in the amphibian world: which way to develop and where to turn? BioEssays 26(5):512–522. https://doi.org/10.1002/bies.20036

Petty, R. G. 1999. Structural asymmetries of the human brain and their disturbance in schizophrenia. Schizophrenia Bulletin 25(1):121–140. https://doi.org/10.1093/oxfordjournals.schbul.a033360

Robichon, F., Levrier, O., Farnarier, P. and Habib, M. 2000. Developmental dyslexia: atypical cortical asymmetries and functional significance. European Journal of Neurology 7(1):35–46. https://doi.org/10.1046/j.1468-1331.2000.00020.x

Singh, K. K. 2013. An emerging role for Wnt and GSK3 signaling pathways in schizophrenia. Clinical Genetics 83:511–517. https://doi.org/10.1111/cge.12111

Sun, T. and Walsh, C. A. 2006. Molecular approaches to brain asymmetry and handedness. Nature Reviews Neuroscience 7:655–662. https://doi.org/10.1038/nrn1930

Trulioff, A. S., Ermakov, A. S. and Malashichev, Y. 2017. Primary cilia as a possible link between left-right asymmetry and neurodevelopmental diseases. Genes 8:48. https://doi.org/10.3390/genes8020048

Vingerhoets, G., Li, X., Hou, L., Bogaert, S., Verhelst, H., Gerrits, R., Slugzdaite, R. and Roberts, N. 2018. Brain structural and functional asymmetry in human situs inversus totalis. Brain Structure and Function 223(4):1937–1952. https://doi.org/10.1007/s00429-017-1598-5