Distinct molecular mechanisms for development of brain asymmetries?

Yegor Malashichev

doi:10.21638/spbu03.2018.201

Authors

Yegor Malashichev Department of Vertebrate Zoology, Faculty of Biology, Saint Petersburg State University, Universitetskaya nab., 7–9, Saint Petersburg, 199034, Russian Federation; Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, ul. Acad. Pavlova, 12, Saint Petersburg, 197376, Russian Federation https://orcid.org/0000-0003-3813-5712

DOI:

https://doi.org/10.21638/spbu03.2018.201

Abstract

Brain and behavioral asymmetries are often associated with neurodevelopmental disorders, but have yet uncovered genetic and developmental mechanisms. A recent study (Vingerhoets et al., 2018), published in Brain Structure and Function, examined neural structural and functional asymmetries in a cohort of patients with situs inversus totalis, with and without primary ciliarly dyskinesia as a second diagnosis. The authors showed a potential for independent randomization of handedness, language dominance, and visceral laterality; this provides the first experimental hint that different mechanisms for symmetry breaking and molecular cascades may be involved in producing asymmetry of body and brain.

Keywords:

brain left-right structural asymmetry, situs viscerum inversus totalis, primary ciliarly dyskinesia, handedness, language dominance, developmental mechanisms, neurodevelopmental diseases

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References

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