Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis
DOI:
https://doi.org/10.21638/spbu03.2019.203Abstract
Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate retrotransposition. If the activity of AID/APOBEC deaminases is misregulated, they can become “weapons of mass destruction,” causing deaminations in unprotected single-stranded DNA regions leading to genome-wide mutagenesis. Ultimately, mutations contribute to cell malignancy and rapid evolution of cancer cells, helping them to evade the organism’s defense. Also, hypermutable tumor cells develop resistance to anti-cancer drugs. Here we overview current understanding of the structure, functions, and regulation of AID/APOBEC cytosine deaminases in connection to carcinogenesis.
Keywords:
Cytosine deaminases AID/APOBEC, DNA damage, mutation, cancer
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2019-08-27
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Zotova, I., Stepchenkova, E., & Pavlov, Y. (2019). Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis. Biological Communications, 64(2), 110–123. https://doi.org/10.21638/spbu03.2019.203
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