Cancer as a potential sequela of COVID-19 — should we modify 3D cell culture models accordingly?

Elena Petersen; Daria Chudakova; Daiana Erdyneeva; Dulamsuren Zorigt; Evgeniya Shabalina; Pavel Karalkin; Igor Reshetov

doi:10.21638/spbu03.2023.307

Authors

Elena Petersen Moscow Institute of Physics and Technology, Institutskiy per., 9, Dolgoprudny, 141701, Russian Federation https://orcid.org/0000-0002-8150-7553
Daria Chudakova Moscow Institute of Physics and Technology, Institutskiy per., 9, Dolgoprudny, 141701, Russian Federation https://orcid.org/0000-0002-9354-6824
Daiana Erdyneeva Moscow Institute of Physics and Technology, Institutskiy per., 9, Dolgoprudny, 141701, Russian Federation https://orcid.org/0000-0003-2279-0157
Dulamsuren Zorigt Moscow Institute of Physics and Technology, Institutskiy per., 9, Dolgoprudny, 141701, Russian Federation https://orcid.org/0000-0001-8133-689X
Evgeniya Shabalina Moscow Institute of Physics and Technology, Institutskiy per., 9, Dolgoprudny, 141701, Russian Federation https://orcid.org/0000-0002-8184-7363
Pavel Karalkin I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), ul. Trubetskaya, 8–2, Moscow, 119991, Russian Federation; P. A. Herzen Moscow Research Institute of Oncology, 2-oy Botkinskiy pr., 3, Moscow, 125284, Russian Federation https://orcid.org/0000-0002-2838-0776
Igor Reshetov I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), ul. Trubetskaya, 8–2, Moscow, 119991, Russian Federation

DOI:

https://doi.org/10.21638/spbu03.2023.307

Abstract

COVID-19 pandemic was caused by SARS-CoV-2, a novel virus from the family Coronaviridae, firstly identified in Wuhan, China in 2019. COVID-19 remains one of the main challenges of healthcare, given growing numbers of people with COVID-19 in anamnesis, and given the long-lasting consequences and complications of this disease. Cancer is one of the most common diseases in the world, thus a big part of the population is affected by both COVID-19 and cancer. In this succinct review we refer to several recent works expressing a view that COVID-19 might be oncogenic, and describe molecular mechanisms of such phenomena. Next, we describe several tumorigenic changes in the tissue microenvironment as COVID-19 sequelae, which can potentially affect cancer pathogenesis and response of a tumor to therapy. 3D cell culture models are a “golden standard” of in vitro studies in translational oncology. To the best of our knowledge, 3D cell culture systems to study tumor behavior in the tissue microenvironment affected by COVID-19 have not been developed yet. We propose several actionable steps which can be taken to modify existing 3D cell culture models accordingly, to address the needs of translational oncology in the COVID-19 post-pandemic times.

Keywords:

COVID-19, SARS-CoV-2, 3D cell culture models, tumor microenvironment, malignant tumors, translational medicine, personalized medicine, drug development, oncology

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