Levels of dopamine, 5-hydroxytryptamine and their metabolites in the striatum of rats of various strains receiving a high-calorie diet

Authors

  • Sergey Apryatin Institute of Experimental Medicine, ul. Akademika Pavlova, 12, Saint Petersburg, 197376, Russian Federation https://orcid.org/0000-0002-6892-4387
  • Evgenia Efimova Institute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya nab., 7–9, Saint Petersburg, 199034, Russian Federation https://orcid.org/0000-0002-9641-515X
  • Zoya Fesenko Institute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya nab., 7–9, Saint Petersburg, 199034, Russian Federation https://orcid.org/0000-0002-2074-9081
  • Antonina Shumakova Federal Research Centre of Nutrition and Biotechnology, Ustyinsky proezd, 2/14, Moscow, 109240, Russian Federation https://orcid.org/0000-0003-1373-4436
  • Ivan Gmoshinski Federal Research Centre of Nutrition and Biotechnology, Ustyinsky proezd, 2/14, Moscow, 109240, Russian Federation https://orcid.org/0000-0002-3671-6508

DOI:

https://doi.org/10.21638/spbu03.2021.405

Abstract

The aim of this work was to study the effect of a high fat and carbohydrate diet (HFCD) and quercetin supplementation on the levels of dopamine (DA), serotonin (5-HT) and their metabolites in Wistar, DA transporter knockout (DAT-KO) and obese Zucker fa/fa rats. Animals received a control diet or HFCD for 62 days. Wistar and Zucker fa/fa rats received quercetin. The contents of DA, 5-HT, norepinephrine (NE), dioxyphenyl acetate (DOPAC), homovanillic acid (HVA) and 5-hydroxyindolyl acetate (5-HIIA) in the striatum were determined by high-performance liquid chromatography (HPLC). DAT-KO homozygotes had lowered DA and increased HVA and DOPAC compared to Wistar rats. HFCD did not affect the content of NE and 5-HT. 5-HT was increased in DAT-KO homozygotes compared with Wistar receiving a control diet. 5-HIIA accumulated in larger amounts in DAT-KO compared to Wistar with the exception of those receiving quercetin with a control diet. Quercetin did not affect the levels of DA, 5-HT and their metabolites.

Keywords:

dopamine, 5-hydroxytryptamine, rats, striatum, fat and carbohydrate excess, quercetin

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References

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Published

2021-12-30

How to Cite

Apryatin, S., Efimova, E., Fesenko, Z., Shumakova, A., & Gmoshinski, I. (2021). Levels of dopamine, 5-hydroxytryptamine and their metabolites in the striatum of rats of various strains receiving a high-calorie diet. Biological Communications, 66(4), 326–332. https://doi.org/10.21638/spbu03.2021.405

Issue

Vol. 66 No. 4 (2021)

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Brief communications

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Articles of Biological Communications are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.