TY - JOUR AU - Khalaman, Vyacheslav AU - Chalisova, Natalia AU - Krasnov, Konstantin AU - Alexandrova, Marina PY - 2019/05/24 Y2 - 2024/03/29 TI - Cytostatic activity in the hydrophilic fraction of the crude extract from the White Sea sponge Halichondria panicea JF - Biological Communications JA - BioComm VL - 64 IS - 1 SE - Full communications DO - 10.21638/spbu03.2019.105 UR - https://biocomm.spbu.ru/article/view/2918 SP - 41–45 AB - <p><em>Halichondria panicea</em>, commonly known as the breadcrumb sponge, is an ecologically aggressive and widespread species in the coastal waters of North Atlantic and North Pacific. Cytostatic activity of the water-soluble extract fraction from the White Sea sponge <em>Halichondria panicea</em> was tested using organotypic cultures of rat liver fragments. The study shows a pronounced negative dose-dependent effect of the extract on the development of tissue explants of the test animals. Our results confirm toxicity of the White Sea <em>Halichondria panicea</em>, which was revealed earlier toward marine epibenthic organisms. The chemical nature of a substance or substances responsible for toxic effect is discussed.</p> ER -