TY - JOUR AU - Dolmatov, Igor AU - Bobrovskaya, Nadezhda AU - Girich, Alexandr PY - 2014/08/17 Y2 - 2024/03/28 TI - Echinoderms as model objects for study of regeneration mechanisms JF - Biological Communications JA - BioComm VL - 0 IS - 3 SE - Full communications DO - UR - https://biocomm.spbu.ru/article/view/1076 SP - 96–112 AB - <p>Echinoderms are convenient model objects for study of regeneration mechanisms. In terms of phylogeny, echinoderms are deuterostomes and therefore have a near common ancestor with vertebrates. Echinoderms can regenerate small body appendages and all internal organs, including nerve system and gonads. Moreover, these animals can regenerate large body regions, like arms or even the whole body after cut in two halves. Good regenerative capacities of echinoderms are the results of mechanisms of dedifferentiation and transdifferentiation but not stem cells. The basis of regeneration of the animals is epithelial morphogenesis. Data cited about cellular mechanisms of regeneration and transcriptome analysis for three species which are most convenient and interesting objects. These are holothurians <em>Eupentacta fraudatrix</em> and <em>Cladolabes schmeltzii</em>, and sea lily <em>Himerometra robustipinna</em>. It was shown that gene families <em>TGF-β, Wnt, Нох</em>, and numerous transcription factors are activated during regeneration in <em>E. fraudatrix</em> and <em>H. robustipinna</em>. Extracellular matrix remodeling during regeneration and fission in holothurians occurred by participation of matrix metalloproteinases, their inhibitors (TIMP), and lysyl oxidase (Lox). Refs 90. Figs 5.</p> ER -