@article{Khalaman_Chalisova_Krasnov_Alexandrova_2019, title={Cytostatic activity in the hydrophilic fraction of the crude extract from the White Sea sponge <em>Halichondria panicea</em>}, volume={64}, url={https://biocomm.spbu.ru/article/view/2918}, DOI={10.21638/spbu03.2019.105}, abstractNote={&lt;p&gt;&lt;em&gt;Halichondria panicea&lt;/em&gt;, commonly known as the breadcrumb sponge, is an ecologically aggressive and widespread species in the coastal waters of North Atlantic and North Pacific. Cytostatic activity of the water-soluble extract fraction from the White Sea sponge &lt;em&gt;Halichondria panicea&lt;/em&gt; was tested using organotypic cultures of rat liver fragments. The study shows a pronounced negative dose-dependent effect of the extract on the development of tissue explants of the test animals. Our results confirm toxicity of the White Sea &lt;em&gt;Halichondria panicea&lt;/em&gt;, which was revealed earlier toward marine epibenthic organisms. The chemical nature of a substance or substances responsible for toxic effect is discussed.&lt;/p&gt;}, number={1}, journal={Biological Communications}, author={Khalaman, Vyacheslav and Chalisova, Natalia and Krasnov, Konstantin and Alexandrova, Marina}, year={2019}, month={May}, pages={41–45} }